2024 Cyclophosphamide induced cardiotoxicity

Cyclophosphamide induced cardiotoxicity

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August undefined, 2024

WebDec 1, 2024 · Cyclophosphamide-induced cardiotoxicity involves multiple mechanisms; oxidative stress, apoptosis, myocardial inflammation, endothelial dysfunction, calcium … WebCyclophosphamide has been used for several decades, but the pathophysiology of cyclophosphamide-induced cardiac toxicity remains poorly understood. The minimum dose for cardiac toxicity is still not known, although there are no reports of cyclophospha- mide toxicity at less than 100 mg/kg.

(PDF) The influence of glutathion S-transferase P-1 polymorphism …

WebApr 11, 2024 · Cyclophosphamide (CTX) is an alkylating agent of nitrogen mustard with broad anti-tumor activity, but excessive or prolonged use can result in toxic s… WebJul 14, 2014 · Cyclophosphamide-induced cardiotoxicity (CIC) is a well-known adverse effect and not that uncommon . Symptoms occur usually within 1 to 3 weeks, and … spout of a kettle

Molecular mechanism involved in cyclophosphamide …

WebFeb 1, 2024 · CP-induced cardiotoxicity ranges from 7 to 28% and mortality ranges from 11 to 43% at the therapeutic dose of 170-180 mg/kg, i.v. CP undergoes hepatic metabolism that results in the production of aldophosphamide. Aldophosphamide decomposes into … WebNov 1, 2024 · Cyclophosphamide (CYP)-induced cardiotoxicity is a common side effect of cancer treatment. Although it has received significant attention, the related mechanisms of CYP-induced cardiotoxicity ... shenyang dean technology co. ltd

Cardiotoxicity following cyclophosphami…

Cyclophosphamide cardiotoxicity - PubMed

WebCardiotoxicity is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and can lead to long term morbidity. The mechanism of anthracycline induced cardiotoxicity seems to involve the formation of free radicals leading to oxidative stress. This may cause apoptosis of … Cardiotoxicity of cytotoxic drugs WebJan 28, 2024 · Background: Cyclophosphamide (CP) (Cytoxan or Endoxan) is an efficient anti-tumor agent, widely used for the treatment of various neoplastic diseases. The study aimed to investigate the protective role of vitamin E (vit E) in improving cardiotoxicity in rats induced by CP. spout mouthWebFeb 7, 2024 · Cyclophosphamide-induced cardiac injury is dose-dependent, with the total dose of a single course of therapy being the best indicator of toxicity, and patients receiving >150 mg/kg or 1.55 g/m 2 /d are at higher risk of cardiotoxicity ( Kusumoto et al., 2013 ). shenyang consulate

"WebPossible protective effects of a methanolic extract of Viscum album (VA) and quercetin (QE) against cyclophosphamide (CP) induced cardiotoxicity, urotoxicity and genotoxicity in mice were evaluated. Mice were administered orally VA (250 mg/kg/day) and QE (50 mg/kg/day) for 10 days alone or in combination with CP. " - Cyclophosphamide induced cardiotoxicity

Cyclophosphamide induced cardiotoxicity

Cyclophosphamide toxicity. Characterising and avoiding the …

WebOct 30, 2012 · Clinically, damage to the bladder (haemorrhagic cystitis), immunosuppression (when not desired) and alopecia are the most significant toxicities associated with cyclophosphamide. Cardiotoxicity is also a possibility when very high doses are given. WebJun 22, 2024 · Cyclophosphamide (CP) is a widely used chemotherapeutic agent but its clinical usefulness is challenged with different forms of toxicities. No studies have evaluated the possible protective effect of nicorandil (NIC) in CP-induced cardiotoxicity.

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WebFeb 5, 2024 · INTRODUCTION. Cyclophosphamide (CP) is widely used in chemotherapy for malignant tumors and as an immunosuppressant for the prevention of graft rejection and treatment of chronic autoimmune diseases.1 It is one of the most effective and safe drugs used for such diseases.2 However, its detrimental side effects cannot be ignored. Thus, … WebJan 10, 2024 · Though mechanism of cyclophosphamide-induced cardiotoxicity is not completely understood, it is thought to encompass oxidative and nitrative stress. As such, this review focuses on …

WebOct 8, 2024 · Administration of Chemotherapeutics, especially doxorubicin (DOX) and cyclophosphamide (CPS), is commonly associated with adverse effects such as myelosuppression and cardiotoxicity. At this time, few approved therapeutic options are currently available for the management of chemotherapy-associated cardiotoxicity. WebAbstract. A 12-year-old boy with aplastic anemia developed severe but reversible cardiac failure after treatment with 200 mg/kg cyclophosphamide (4 x 50 mg/kg on four …

WebJul 14, 2014 · Cyclophosphamide-induced cardiotoxicity was suspected and she was given treatment for congestive heart failure. Her dyspnea decreased and she was discharged on the tenth day with a left ventricular ejection fraction of 37% and normal right ventricular function. WebNational Center for Biotechnology Information

WebApr 12, 2024 · Request PDF On Apr 12, 2024, Sarmad Hayder and others published Effect of Cyclophosphamide on the Biosystem Find, read and cite all the research you need on ResearchGate

WebNov 8, 2024 · The Role of METTL3-Mediated N6-Methyladenosine (m6A) of JPH2 mRNA in Cyclophosphamide-Induced Cardiotoxicity The Role of METTL3-Mediated N6-Methyladenosine (m6A) of JPH2 mRNA in Cyclophosphamide-Induced Cardiotoxicity Front Cardiovasc Med. eCollection 2024. Authors shenyang earthquakeWebJun 1, 2016 · PDF ABSTRAK Latar belakang: Kemoterapi sering menimbulkan efek samping berupa toksisitas hematologi. Derajat toksisitas yang timbul sering dikaitkan... Find, read and cite all the research you ... spout of garnock walkWebOct 8, 2024 · Our study validates the involvement of oxidative stress in Doxorubicin and Cyclophosphamide-induced cardiotoxicity . Interleukin-converting enzyme (ICE, … spout of teapot crosswordWebCardiotoxicity commonly refers to toxicity that has a detrimental impact on the heart, which might finally lead to myocardiopathy such as arrhythmia, myocardial infarction and myocardial hypertrophy. These inevitable side effects, especially of anticancer drugs, are usually the main causes of treatment termination and drug development failure. shenyang covid newsWebHighly differing rates of cardiac complications associated with high-dose cyclophosphamide have been reported. To date, no systematic clinical study has investigated high-dose cyclophosphamide mobilization regimens in multiple myeloma patients and evaluated its cardiotoxicity. shenyang east chemical science-tech co. ltdWebCyclophosphamide toxicity. Characterising and avoiding the problem Cyclophosphamide, an orally active alkylating agent, is widely used to treat a variety of malignant and nonmalignant disorders. Although it has some tumour selectivity, it also possesses a wide spectrum of toxicities. shenyang eisen pet products co. ltdWebMar 24, 2024 · Cyclophosphamide, which can inhibit DNA replication and apoptosis, is a kind of DNA-alkylating agent for breast cancer, cyclophosphamide-induced cardiac damage is dose dependent, and mechanisms of cyclophosphamide-induced cardiotoxicity encompass oxidative and nitrative stress and protein adduct formation. shenyang dragon flag technology co. ltd